Benevolent NAD+ Supplement 1050mg Review: A 3-in-1 NAD Booster Tested

NAD+ levels drop as you age, and that decline affects everything from how much energy your cells produce to how well your body repairs DNA. Nicotinamide adenine dinucleotide, commonly known as NAD+, is a coenzyme involved in redox reactions and cellular respiration across every cell in the human body. The Benevolent NAD+ Supplement aims to address age-related NAD+ decline with a 1050mg three-ingredient formula combining nicotinamide riboside, trimethylglycine, and trans-resveratrol.

I spent time examining this dietary supplement’s ingredient panel, dosage strategy, and how it stacks up against other oral NAD supplements on the market. The 600mg NR dose is competitive, and the inclusion of TMG addresses a methylation concern that most single-ingredient NAD+ boosters overlook.

The result is a solid mid-range option for anyone exploring anti-aging NAD supplementation for cellular energy and healthy aging support, though it comes with a few trade-offs worth knowing about.

What I Liked About the Benevolent NAD+ Supplement

Strong Nicotinamide Riboside Dosage

The 600mg of nicotinamide riboside per serving puts this supplement in competitive territory. NR is a form of vitamin B3 and nicotinic acid derivative that your body converts into NAD+, the cofactor required for over 500 enzymatic reactions in human physiology. A randomized controlled trial of nicotinamide riboside supplementation showed that taking an NAD precursor at this dose can increase blood NAD+ levels by approximately 60% within six weeks in healthy men and women.

Many NAD supplements on the market use 300mg or less of NR. The Benevolent formula doubles that, which aligns with research suggesting higher doses produce more meaningful changes in the level of NAD within cells. The effectiveness of NAD supplementation with NR at this dose range has been documented across multiple clinical trials, and customer reviews consistently highlight noticeable improvements in energy within the first month.

Smart Combination With TMG for Cellular Energy

The 300mg of trimethylglycine addresses a problem most standalone NR supplements ignore. When your body metabolizes NAD+ precursors, it uses up methyl groups. Without replenishment, this can lead to elevated homocysteine, a cardiovascular risk marker that some NAD+ users have reported seeing spike in blood work.

TMG acts as a methyl donor, helping maintain NAD+ metabolism balance while you boost NAD+ levels. This formulation shows the brand understands the effects of nicotinamide on methylation pathways, not just the headline ingredient. Supplementation with NAD precursors without methyl support can deplete methyl reserves over time, making TMG a smart addition.

Trans-Resveratrol for Antioxidant Protection

The 150mg of trans-resveratrol works synergistically with NR. Resveratrol activates sirtuins, the enzymes responsible for DNA repair and cellular longevity, and these enzymes require NAD+ as fuel. Research has shown that nicotinamide mononucleotide combined with resveratrol improves NAD+ levels in heart and skeletal muscle better than NMN alone, and NR follows a similar pathway through the NAD+ salvage cycle.

By pairing an NAD+ precursor with a sirtuin activator, the formula creates a complementary cycle where both ingredients amplify each other’s effects on bioenergetics and cellular energy production. The potential benefits of this NAD supplement with resveratrol extend to improved cognition and reduced inflammation markers in preclinical studies.

Third-Party Tested and Made in the USA

The supplement is manufactured in a GMP-certified facility in the United States and undergoes third-party laboratory testing. The Food and Drug Administration does not approve dietary supplements before they reach store shelves, which makes independent testing a meaningful differentiator. For a supplement category where a study found most NMN products contained less of the active ingredient than advertised, that verification matters.

The capsules are also vegan, non-GMO, and free from common allergens, making them accessible to a wide range of dietary preferences. This level of transparency is worth noting when you use NAD supplements as part of a daily health routine.

Supports DNA Repair and Mitochondrial Function

NAD+ plays a direct role in mitochondrial function and adenosine triphosphate production, the molecule that fuels every process in your cells. The mitochondrion relies on NAD+ as a coenzyme in cellular respiration, and when you maintain adequate levels of NAD through NR supplementation, you support the energy production pathway that naturally declines with ageing.

Users in longevity communities report noticing improved energy levels within the first few weeks of nicotinamide riboside supplementation. One user documented that their total testosterone increased, hair became thicker, and sleep quality improved after consistent NAD+ precursor use. These benefits of NAD supplementation align with what researchers observe in clinical settings, though individual responses vary depending on baseline NAD+ status, age, and overall health. Starting your NAD regimen earlier rather than later may help maintain cellular function before significant age-related decline sets in.

What Needs Improvement

Only a 30-Day Supply Per Bottle

At three capsules per serving, the 90-capsule bottle lasts exactly 30 days. Competitors such as Tru Niagen offer single-capsule servings, making their supply stretch further. If you take NAD supplements consistently as a daily habit, the per-month cost adds up and the multiple capsule format is less convenient for travel.

Limited Long-Term Clinical Evidence

While short-term clinical trials on NR and NMN supplementation show safety and an increase in NAD levels, there are no long-term human safety trials evaluating NAD+ boosters beyond 12 weeks. Most reported adverse effects are mild, including nausea, headaches, and digestive discomfort, but the long-term picture remains incomplete. The effects of NAD supplementation on chronic conditions and disease prevention have not been established in therapy-grade studies. Anyone with a history of cancer or inflammatory conditions should consult their physician before starting NAD+ supplementation.

No Clinical Trials on This Specific Formula

The individual ingredients have research backing, but Benevolent has not published clinical trials on their specific combination or dosage ratios. This is common across the NAD+ supplement market, but supplements may vary in their effectiveness depending on formulation quality. You are relying on extrapolated research from NAD and its precursors rather than direct evidence for this particular product.

Potential Digestive Discomfort

Some users of NAD+ precursors report mild gastrointestinal issues, particularly when starting supplementation or taking capsules on an empty stomach. The 1050mg total dose per serving is a substantial amount of any vitamin or acid compound to take at once, and users with sensitive stomachs may need to split the dose or take it with food to raise NAD levels more gradually.

How the Benevolent NAD+ Compares to Other NAD Supplements

Benevolent NAD+ vs. Tru Niagen

Tru Niagen uses the patented Niagen form of nicotinamide riboside backed by over 40 published human clinical studies. It delivers 300mg of NR as a drug-grade nucleotide in a single capsule at around $116 for 30 servings. The Benevolent formula doubles the NR dose at roughly a third of the price, but lacks the same depth of clinical validation. If research credibility is your priority, Tru Niagen has the edge. If you want a higher NR dose with TMG support at a lower cost, Benevolent offers better value.

Benevolent NAD+ vs. Omre NMN + Resveratrol

Omre takes a different NAD precursor approach with 500mg of nicotinamide mononucleotide paired with 500mg of resveratrol. NMN and NR both boost NAD+ levels through different pathways. An NMN supplement has demonstrated benefits for insulin sensitivity and eye function that NR has not, while NR shows unique neuroprotective properties. Omre uses NMN while Benevolent uses NR, so your choice depends on which precursor pathway you prefer.

Benevolent NAD+ vs. Innerbody Labs NAD+ Support

The Innerbody Labs formula combines 700mg NMN and 400mg NR with TMG and spermidine, offering the most comprehensive NAD+ supplementation approach. At a higher price point, it covers both major precursor pathways and includes additional methyl support. For someone willing to invest more, the dual-precursor strategy may provide broader coverage and a higher overall level of NAD elevation. The Benevolent formula is a simpler, more affordable entry point into NAD+ supplementation with solid NR dosing.

Final Verdict

The Benevolent NAD+ Supplement earns a 4.2 out of 5 for delivering a well-formulated, competitively dosed NAD+ booster at a reasonable price. The 600mg nicotinamide riboside paired with TMG and trans-resveratrol addresses the core needs of NAD supplementation while accounting for methylation balance, something many competitors skip.

The main drawbacks are the 30-day supply from a 90-capsule bottle and the lack of brand-specific clinical trials. For the dietary supplement category, those are common limitations rather than red flags. Customer reviews on Amazon confirm that most users tolerate the formula well and report positive results within weeks of consistent use.

Bottom line: if you are looking to start your NAD supplementation journey with a formula that combines NAD precursors with supporting food-derived ingredients at a price under $45, the Benevolent NAD+ is a smart entry point that delivers on the fundamentals. Whether your goal is to increase NAD levels for anti-aging purposes or to maintain NAD for daily energy and risk reduction, this three-in-one approach covers the basics without overcomplicating the process. For anyone ready to take their first step into NAD+ supplementation, the Benevolent formula provides a balanced starting point at a price that does not require a major commitment.